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Important Announcement - For Travel Information Please Click on the "ABSTRACTS" Button
PRELIMINARY SCHEDULE
Dates: September 24 - 27, 2008
Location: Mohonk Mountain House, New Paltz, NY
Conference organizers:
Betty Diamond, M.D.
Head, Autoimmune Disease Center
The Feinstein Institute for Medical Research
North Shore – LIJ Health System
Manhasset, New York 11030
Peter K. Gregersen, M.D.
Head, Boas Center for Genomics & Human Genetics
The Feinstein Institute for Medical Research
North Shore – LIJ Health System
Manhasset, New York 11030
Timothy Behrens, M.D.
Senior Director, ITGR Exploratory Clinical Development
Genentech
South San Francisco, California 94080
Wednesday
September 24, 2008
| 12 noon |
Arrival and assembly at |
| 12:30 PM | Overview of the FIMR - Refreshments |
| 1:15 PM | Board Buses for Departure to Mohonk Mountain House |
| 4:00 - 6:00 PM | Registration & Refreshments |
| 6:00 - 6:15 PM | Welcome and Introduction Dr. Betty Diamond Conference Co-Chair |
| 6:15 - 7:15 PM | Plenary Lecture: Michel Nussenzweig, MD, PhD “Antibody Tolerance in Humans” |
| 7:15 - 8:00 PM | Cocktail Reception |
| 8:00– 10: PM | Welcome Dinner |
Thursday
September 25, 2008
| 7:00 - 8:00 AM | Breakfast |
| Session I | 8:00 AM - 12:30 PM |
Induction of Autoreactivity – Triggers and Innate Immunity
Co-Chairs: Dr. Anne Davidson, Dr. Judith James
| 8:00 AM - 8:25 AM | Antony Rosen “Autoantigen Expression and Modification” |
| 8:25 AM–8:50 AM | Sylvia Bolland “TLR1 and other modifiers of systemic autoimmune disease” |
| 8:50 AM - 9:15 AM | Martin Herrmann “Autoimmunity and chronic inflammation - two clearance-related steps in the etiopathogenesis of SLE” |
| 9:15 AM - 9:40 AM | Kevin Tracey “Inflammatory reflex: Neural regulation of immune response” |
| 9:40 AM -10:05 AM | Coffee Break |
| 10:05 AM -10:30AM | Gregg Silverman “Natural antibody regulation of innate immunity" |
| 10:30-10:55 AM | Peggy Crow “Autoimmunity and Inflammation Research” |
| 10:55-11:20 AM | Moncef Zouali “Autoimmunity and Tolerance: Tracking Autoreactivity to its Source” |
| 11:20- 11:45AM | Judith James “Early Events in Lupus Autoimmunity” |
| 12:00 – 2:30 PM | Lunch, Free Time |
| Session II | 2:30 PM – 6:30 PM |
Adaptive Immunity – Animal models
Co-Chairs: Dr Thomas L. Rothstein, Dr. Alessandra Pernis
| 2:30 PM - 2:55 PM | Joe Craft “Pathogenic T Helper Cell Subsets in Autoimmunity” |
| 2:55 PM -3:20 PM | Christine Grimaldi “Regulation of autoreactivity in the transitional B cell repertoire” |
| 3:20 PM - 3:45 PM | Edward Wakeland “Modeling genetic susceptibility to systemic autoimmunity in the mouse” |
| 3:45 PM - 4:10 PM | Alessandra Pernis “Novel signaling pathways in lupus research” |
| 4:10 PM - 4:30 PM | Coffee Break |
| 4:35 PM -5:00 PM | Thomas Rothstein “Imprinting an alternate pathway for B cell receptor signaling” |
| 5:00 PM - 5:25 PM | Barbara Vilen “Regulation of Autoreactive B cells during Innate Immune Responses” |
| 5:25 PM - 5:50 PM | Gary Gilkeson “Estrogen receptor effects on lupus and the innate immune response” |
| 5:50 PM - 6:15 PM | Anne Davidson “BAFF blockade in SLE” |
| 6:30 PM - 8:30 PM | Dinner |
| 8:30 PM – 10:30 PM | Posters |
Friday
September 26, 2008
| 7:00 - 8:00 AM | Breakfast |
| Session III | 8:00 AM - 12:30 PM |
Human Disease and Tissue Responses
Co-Chairs: Dr. Betty Diamond, Dr. Susan Manzi
| 8:00 AM -8:25 AM | Susan Manzi “The Pittsburgh Lupus Center: A Model for Translational Research” |
| 8:25 AM–8:50 AM | Shiv Pillai “SLE mutations in autoimmunity” |
| 8:50 AM - 9:15 AM | Ignacio Sanz “B cell tolerance and homeostasis in human SLE” |
| 9:15 AM-9:35 AM | Virginia Pascual “Gene Expression Profiling in SLE” |
| 9:35 AM-10:05 AM | Coffee Break |
| 10:05 AM-10:30AM | Jill Buyon “Neonatal Lupus: Linking Anti-SSA/Ro Antibodies to Cardiac Fibrosis” |
| 10:30 AM-10:55AM | Jorge Sanchez-Guerrero “Serum and Cereborspinal Fluid Autoantibodies in Patients with Neuropsychiatric Lupus Erythematosus: Implications for Diagnosis and Pathogenesis” |
| 10:55 AM -11:20AM | Jane Salmon “Mediators and Mechanisms of Pregnancy Complications in SLE: Translational Studies” |
| 11:20AM- 11:45AM | Johan Frostegård “Natural antibodies against phosphorylcholine as protection factors in SLE and cardiovascular disease” |
| 12:00 – 2:30 PM | Lunch, Free Time |
| Session IV | 2:30 PM – 6:30 PM |
Adaptive Immunity – Human disease
Co-Chairs: Dr. Timothy Behrens, Dr. David Wofsy
| 2:30 PM - 2:55 PM | Keith Elkon “Neuropsychiatric SLE, old and new” |
| 2:55 PM - 3:15 PM | Thomas Dörner “Disturbances of memory B cells in SLE” |
| 3:15 PM - 3:35 PM | Peter Lipsky “B cells and Human Lupus” |
| 3:35 PM - 4:00 PM | David Wofsy “Clinical trial in SLE: Promises and Paradoxes” |
| 4:00 PM - 4:25 PM | Coffee Break |
| 4:25 PM - 4:55 PM | Marcus Clark “Rethinking Human Lupus Nephritis” |
| 4:55 PM - 5:20 PM | Stuart Tangye “Regulation of human B cell differentiation by T follicular helper cells: implications for autoimmune diseases” |
| 5:20 PM - 5:45 PM | Thomas Winkler “Evolution and pathogenicity of human anti-DNA autoantibodies” |
| 5:45 PM - 6:10 PM | Robert Clancy “Widespread upregulation of membrane Endothelial Protein C Receptor in the vasculature of patients with active nephritis and more advanced renal insufficiency” |
| 6:30 PM - 9:00 PM | Gala Dinner |
Saturday
September 27, 2008
| 7:00 - 8:30 AM | Breakfast |
| Session V | 8:30 AM - 11:30 PM |
Genes and Gene Expression
Co-Chairs: Dr. Marta Alarcon-Riquelme, Dr. Peter K. Gregersen
| 8:30 - 8:55 AM | Timothy Behrens “Genes and Gene Expression” |
| 8:55 – 9:20 AM | Nunzio Bottini “Lupus-associated PTPN22-R620W Polymorphism causes gain-of-function by altering feedback between a kinase and a phosphatase” |
| 9:20 - 9:45 AM | John Harley “Genes for Lupus: Toward the Genetic Architecture in an Underpowered World” |
| 9:45 - 10:10 AM | Coffee Break |
| 10:10 - 10:35 AM | Emily Gillespie “Interferon-regulated biomarkers of SLE disease activity” |
| 10:35 - 11:00 AM | Laurence Morel “Chasing genes involved in tolerance to nuclear antigens” |
| 11:00 - 11:25 AM | Marta Alarcon-Riquelme “The role of the B-cell gene BANK1 in Susceptibility for SLE” |
| 11:30 AM | Closing Remarks |
| 11:30 AM - 12:00 Noon | Boxed Lunches |
| 12:15 PM | Buses leave Mohonk for airports, FIMR. |